A Pixel-Encoder Retinal Ganglion Cell with Spatially Offset Excitatory and Inhibitory Receptive Fields

A Pixel-Encoder Retinal Ganglion Cell with Spatially Offset Excitatory and Inhibitory Receptive Fields

Blog Article

Summary: The spike trains of retinal ganglion cells (RGCs) are the only source of visual information to the brain.Here, we genetically identify Accessories an RGC type in mice that functions as a pixel encoder and increases firing to light increments (PixON-RGC).PixON-RGCs have medium-sized dendritic arbors and non-canonical center-surround receptive fields.From their receptive field center, PixON-RGCs receive only excitatory input, which encodes contrast and spatial information linearly.From their receptive field surround, PixON-RGCs receive only inhibitory input, C1000 DELAYED RELEASE which is temporally matched to the excitatory center input.

As a result, the firing rate of PixON-RGCs linearly encodes local image contrast.Spatially offset (i.e., truly lateral) inhibition of PixON-RGCs arises from spiking GABAergic amacrine cells.The receptive field organization of PixON-RGCs is independent of stimulus wavelength (i.

e., achromatic).PixON-RGCs project predominantly to the dorsal lateral geniculate nucleus (dLGN) of the thalamus and likely contribute to visual perception.